Scientific Research Publishing

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53400#.VMCN2izQrzE Author(s)     Pedram Rafiei , Deborah Michel , Azita Haddadi Affiliation(s) Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada . ABSTRACT Docetaxel is a member of taxan family of antineoplastic agents widely used in cancer chemotherapy. However, application of conventional chemotherapy with commercial formulation has been accompanied with matters of concern regarding drug’s biodistribution, pharmacokinetics, and pharmacodynamics. Polymeric nanoparticles have been widely used as unique drug delivery vehicles to circumvent such problems. Docetaxel-loaded poly (lactide-co-glycolide) (PLGA) and poly (lactide-co-glycolide)-poly (ethylene glycol) (PLGA-PEG) nanoparticles fit well in modifying drug’s pharmacokinetic characteristics as intravenous (IV) sustained-release delivery vehic...

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53000#.VK9BqsnQrzE Author(s)   Diego J. S. Dias 1,2 , Graziella A. Joanitti 3 , Ricardo B. Azevedo 2 , Luciano P. Silva 4 , Claure N. Lunardi 1,3 , Anderson J. Gomes 1,3*   Affiliation(s) 1 School of Health Sciences, University of Brasilia, Brasilia, Brazil . 2 Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil . 3 Laboratory of Nanobiotechnology, Faculty of Ceilandia, University of Brasilia, Brasilia, Brazil . 4 Laboratory of Mass Spectrometry, EMBRAPA, Genetic Resources and Biotechnology, Brasilia, Brazil . ABSTRACT The present work aimed to develop and evaluate a colloidal system composed of poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) associated with chlorambucil (CHB) and its effects on cancer cells. The nanoparticles showed %EE (>92%), a mean particle size in the range of 240 to 334 nm and zeta potential of -16...

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52929#.VKyjCcnQrzE Author(s)    Anamaria Teodora Coêlho Rios Silva , Barbara Camilla Oliveira Cardoso , Maria Elisa Scarpelli Ribeiro e Silva , Roberto Fernando Souza Freitas , Ricardo Geraldo Sousa *   Affiliation(s) Polymer Science and Technology Laboratory, Chemical Engineering Department, School of Engineering, Federal University of Minas Gerais, Belo Horizonte, Brazil . ABSTRACT The poly(lactic-co-glycolic acid), known as PLGA, is one of the main bioreabsorbable polymers used in the field of medicine today. This copolymer is widely applied in sutures, devices geared toward the controlled release of medication, and the guided regeneration of bone tissue as it presents a short degradation time. This work aimed to synthesize the 82/18 PLGA (expressed by the mass ratio of D,L-lactide and glycolide, respectively), to characterize and study the in...