Microarray Analysis of Transcriptomic Response of Escherichia coli to Nonthermal Plasma-Treated PBS Solution
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53711#.VNBuDyzQrzE Author(s) Suresh G. Joshi 1,2* , Adam Yost 2 , Siddharth S. Joshi 2 , Sankar Addya 3 , Garth Ehrlich 1 , Ari Brooks 1,4 Affiliation(s) 1 Center for Surgical Infection and Biofilm, College of Medicine, Drexel University, Philadelphia, USA . 2 School of Biomedical Engineering, Science and Health, Drexel University, Philadelphia, USA . 3 Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA . 4 Department of Surgery, University of Pennsylvania Health System, Philadelphia, USA . ABSTRACT We developed a technique of generating nonthermal atmospheric plasma-activated solution that had broad-spectrum antibacterial properties. Plasma-activated phosphate-buffered saline (PBS) causes rapid inactivation of bacteria following generation oxidative stress. However, dose optimization requires understanding of cellular mechanis...