In Vitro Effect of Soy Isoflavone and Equol on Soluble CD40L Release Stimulated by Ristocetin in Platelets from Postmenopause Women
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53275#.VLxqX8nQrzE Author(s) Natalia Gonzalez , Argelia Garrido , Ingrid Acevedo , Luis Valladares * Affiliation(s) Institute of Nutrition and Food Technology, Universidad de Chile, Santiago, Chile . ABSTRACT The inhibition of specific flavonoid on the in vitro platelet aggregation induced by collagen, arachidonic acid and thromboxane A2 (TxA2) agonist, seems to be related mostly to their ability to compete for binding to the TxA2 receptor (TP). The aim of this study was to analyze the effect of soy isoflavone and equol in terms of inhibiting the platelet aggregation and sCD40L release stimulated by ristocetin, an in vitro -activator of glycoprotein Ib/IX/V, in platelets from postmenopausal women. When platelets were stimulated by 0.75 mg/ml ristocetin, equol (10 μM) exhibited a greater inhibitory activity on platelet aggregation (~68%) than...