Scientific Research Publishing

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50935#.VFCBLFfHRK0 Author(s) Blake R. Sonne , Nachum Dafny * Affiliation(s) Department of Neurobiology and Anatomy, The University of Texas—Medical School at Houston, Houston, TX, USA . ABSTRACT Methylphenidate (MPD), known as Ritalin, is a common drug prescribed for those diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).There are reports that many MPD users consume alcohol, resulting in toxic effects and hospitalization. The goal of this study was to investigate the effects of ethanol in rats concomitant with acute and repetitive MPD exposure. Rats were divided into four groups, control (saline), 0.6 mg/kg MPD, 2....

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50717#.VEmpg1fHRK0 Author(s)     Takashi Ikeno 1,2* , Kiyotaka Kugiyama 2 , Hiroto Ito 1,2 Affiliation(s) 1 Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan . 2 Faculty of Medicine, Graduate School of Medical Science, University of Yamanashi, Yamanashi, Japan . ABSTRACT Objective: To identify the effects of antipsychotics on QTc prolongation in light of age, gender, antipsychotic combination pattern, antipsychotic doses and cytochrome P450 (CYP) mediation, using large database describing the antipsychotic treatment of patients with schizophre...