Stereoselective Aldol Reaction in Aqueous Solution Using Prolinamido-Glycosides as Water-Compatible Organocatalyst
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53042#.VLSJdcnQrzE Author(s) Daisuke Miura * , Tomoya Machinami Affiliation(s) Department of Chemistry, College of Science and Technology, Meisei University, Hino, Tokyo, Japan . ABSTRACT Prolinamido-glycoside catalyzed asymmetric aldol reaction in aqueous media is reported. The reactions are rapid and highly stereoselective when water is used as solvent. The stereoselectivities were under influence of configurations of a prolyl residue of the catalyst and α-chiral aldehydes. Water soluble prolinamido-glycoside catalysts are easily separable from reaction mixture and can be recycled and re-used several times. KEYWORDS Organocatalyst , Aldol Reaction , Carbohydrate , Water-Compatible , Prolinamide Cite this paper Miura, D. and Machinami, T. (2015) Stereoselective Aldol Reaction in Aqueous Solution Using Prolinamido-Glycosides as Wat...