Preparation of Polyfunctionally Substituted Pyridine-2(1H)-Thione Derivatives as Precursors to Bicycles and Polycycles
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52833#.VKn-icnQrzE Author(s) Fathi A. Abu-Shanab 1,2* , Sayed A. S. Mousa 1 , Sherif M. Sherif 3 , Mohamed I. Hassan 1 Affiliation(s) 1 Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, Egypt . 2 Department of Chemistry, Faculty of Science, Gazan University, Gazan, KSA . 3 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt . ABSTRACT Reaction of acetylacetone with 1 mole of dimethylformamide dimethyl acetal (DMFDMA) affords enamine 2a which reacts with cyanothioacetamide to give pyridinethione 3a. Pyridinethione 3a reacts with methyl iodide, halogenated compounds, aromatic alde...