Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=54114#.VO2EgyzQrzE Author(s) Mohammed Adam Kunna 1 , Tuty Asmawaty Abdul Kadir 1 , Aqeel S. Jaber 2 , Julius B. Odili 1 Affiliation(s) 1 Faculty of Computer System and Software Engineering, Universiti Malaysia Pahang, Kuantan, Malaysia . 2 Faculty of Electrical and Electronic Engineering, Universiti Malaysia Pahang, Kuantan, Malaysia . ABSTRACT In metabolic network modelling, the accuracy of kinetic parameters has become more important over the last two decades. Even a small perturbation in kinetic parameters may cause major changes in a model’s response. The focus of this study is to identify the kinetic parameters, using two distinct approaches: firstly, a One-at-a-Time Sensitivity Measure, performed on 185 kinetic parameters, which represent glycolysis, pentose phosphate, TCA cycle, gluconeogenesis, glycoxylate pathways, and acetate formation. Tim...
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