Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53118#.VLXOUsnQrzE Author(s) Udaya M. Kabadi 1,2,3* , Mary U. Kabadi 1 , Sommany Weber 3 , Aaron Bubolz 3 , Edward Finnerty 3 Affiliation(s) 1 University of Iowa Carver College of Medicine, Iowa City, Iowa, USA . 2 VA Medical Center, Phoenix, Arizona, USA . 3 Des Moines University, Des Moines, Iowa, USA . ABSTRACT Background: UKPDS suggested relentless deterioration of β cell function as a part of natural course of type 2 diabetes mellitus. However, the course was apparently not universal since many patients maintained glycemic goal (HbA1c < 7.0%) at 9 years while receiving conventional life style programs consisting of diet and exercise or/and oral agents. Moreover, β cell failure occurred around the same time as the time of onset of microvascular complications. Finally, the exact mechanism of progressive β cell failure remains to be def...
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