Simvastatin Potentiates the Antihyperglycemic, Antidyslipidimic and Antioxidative Effect of Glibenclamide on Alloxan-Induced Diabetic Rats
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50979#.VFHKv1fHRK0 Author(s) Mst. Marium Begum , A. F. M. Towheedur Rahman , Saiful Islam , Md. Asaduzzaman , Hazrat Ali , Yusuf Ali , Shaheda Zannah , A. H. M. Khurshid Alam , Md. Aziz Abdur Rahman , Mamunur Rashid * Affiliation(s) Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh . ABSTRACT The aim of the current study is to investigate the effect of combination of glibenclamide; an antidiabetic drug and simvastatin; a HMG-CoA reductase inhibitor on long-term (four weeks) alloxan-induced diabetes rats (ADRs). Methods: Alloxan (120 mg/kg body weight, BW) was injected intra-peritonially (i.p.) in rats. A...