The Endocannabinoid, 2-Arachidonoyl Glycerol, Induces Growth Cone Collapse and Neurite Retraction in Growing Peripheral Sensory Neurons
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53187#.VLcfFMnQrzE Author(s) Chizu Aso 1 , Tomonori Takazawa 2* , Tatsuo Horiuchi 2 , Shigeru Saito 2 Affiliation(s) 1 Department of Anesthesiology, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan . 2 Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan . ABSTRACT Cannabis has a detrimental impact on the developing nervous system. Therefore, regular consumption of cannabis by pregnant and lactating woman poses a potential risk to neuronal growth in fetuses and infants. Indeed, endogenous cannabis-like molecules called endocannabinoids regulate many physiological processes, including neurogenesis, axon guidance, and synaptic plasticity through CB1 receptors. To investigate the physiological role of CB1 receptors on peripheral sensory nerve growth, the endocannabinoid 2-arachidonoy...