Scientific Research Publishing

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50849#.VE3YfVfHRK0 Author(s)   Ming Li 1 , Tao Yang 1 , Fujun Dai 2 , Qian Li 2 , Yahong Zhang 2 , Songqiang Xie 1* , Chaojie Wang 2* Affiliation(s) 1 Institute of Chemical Biology, Pharmaceutical College of Henan University, Kaifeng, China . 2 The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China . ABSTRACT Natural polyamine is an ideal antitumor drug carrier because of the great requirement difference between cancer cells and normal cells. Previous data demonstrated that many cytotoxic drugs conjugated with natural or synthetic polyamines have potent antitumor effects. Up to now,...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50849#.VE3YalfHRK0 Author(s)   Ming Li 1 , Tao Yang 1 , Fujun Dai 2 , Qian Li 2 , Yahong Zhang 2 , Songqiang Xie 1* , Chaojie Wang 2* Affiliation(s) 1 Institute of Chemical Biology, Pharmaceutical College of Henan University, Kaifeng, China . 2 The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China . ABSTRACT Natural polyamine is an ideal antitumor drug carrier because of the great requirement difference between cancer cells and normal cells. Previous data demonstrated that many cytotoxic drugs conjugated with natural or synthetic polyamines have potent antitumor effects. Up to now,...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50686#.VEiSa1fHRK0 Author(s)   Sayed Abdel Raheem , Abdel Naby Saied , Rabee Al Shaer , Osama Mustafa , Ali Hassan Ali Affiliation(s) Departments of Pathology and Anatomy, Faculty of Medicine, Al Azhar University, Cairo, Egypt . ABSTRACT Background: Differentiation of urothelial hyperplasia, dysplasia and carcinoma in situ (CIS) may pose diagnostic difficulties. We aim to evaluate the role of CK20, p53 and p63 in differentiation of such lesions. Methods: we evaluate these markers in 213 cases of bladder lesions (14 hyperplasia, 7 dysplasia, 5 CIS, 25 noninvasive and 162 invasive urothelial carcinoma) in a retrospective study on...