Progressive Obesity in Female Rats from Synergistic Interactions between Drugs and Whole Body Application of Weak, Physiologically Patterned Magnetic Fields
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=47406#.VMiWVizQrzE Author(s) Linda S. St-Pierre , Michael A. Persinger Affiliation(s) Behavioural Neuroscience Program, Laurentian University, Sudbury, Canada . Behavioural Neuroscience Program, Laurentian University, Sudbury, Canada . ABSTRACT Prepubescent female rats treated with the atypical neuroleptic acepromazine but not ketamine, prazosin, or doxepin, after lithium/pilocarpine-induced seizures gradually became obese over their lifetimes if spontaneous seizures developed. Mild increases in weight gain were induced when prepuberal females were given pilocarpine and acepromazine while being exposed briefly (1.5 hr) to a frequency-modulated magnetic field known to induce seizures. Weekly (1.5 hr) exposures to physiologically-patterned magnetic fields over 36 wks had no effect on weight gain while continuous periseizure exposure to 50 Hz fields above about 1...