Scientific Research Publishing

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=45290#.VL30GCzQrzE Author(s)    Dominique Ansell , Julie Grandbois , T. C. Tai Affiliation(s) Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . ABSTRACT Nitric oxide (NO) regulates a wide range of physiological processes. Recent studies show that NO can regulate the release of catecholamines (CA) from the adrenal medulla. In the current study, the PC12 cell line was used to examine the effect of NO on the regulation of the CA biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine- β -hydroxylase (DBH) and phenylethanolamine Nmethyltransferase (PNMT). Treatment of PC12 cells with the NO donor, sodium nitroprusside (SNP) for 6 hours significantly increased TH, DBH and PN...

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53022#.VLR-kMnQrzE Author(s)     Sandhya Shresthra 1 , Daniel Juneau 2 , Daniel Hermann 2 , Gretchen L. Wells 2*   Affiliation(s) 1 Section on Pulmonary/Critical Care Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, USA . 2 Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, USA . ABSTRACT Apical ballooning syndrome (Takotsubo cardiomyopathy) is an increasingly recognized form of acute systolic dysfunction which is usually reversible. It typically occurs in post-menopausal women following a major psychological stressor. We conducted a single center, retrospective analysis of all hospitalized patients from 2001-2012 and found 104 patients who met the diagnostic criteria for apical ballooning. In this current largest series of its kind, 83% of...