Read full paper at： http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53130#.VLXUD8nQrzE Author(s) Huimin Liu , Jing Geng , Zhimin Liu , Baoguo Liu * Affiliation(s) Department of Dermatology and Venereology, Affiliated Hospital of Hebei Engeering University, Handan, China . ABSTRACT Objective: To evaluate the clinical significance of high mobility group box 1 (HMGB1) expression in nephridial tissues of lupus nephritis (LN). Methods: Sixty-three patients with active LN and 15 systemic lupus erythematosus (SLE) (combined without LN) were included. Renal biopsies were performed in the two groups. The biopsies were evaluated according to the World Health Organization (WHO) classification and renal disease activity was estimated using the British Isles lupus assessment group (BILAG) index. Serum levels of HMGB1 were analyzed by western blot. HMGB1 expression in renal tissue was assessed by immunohistochemistry in the tw...
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