Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=45290#.VL30GCzQrzE Author(s) Dominique Ansell , Julie Grandbois , T. C. Tai Affiliation(s) Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Canada . ABSTRACT Nitric oxide (NO) regulates a wide range of physiological processes. Recent studies show that NO can regulate the release of catecholamines (CA) from the adrenal medulla. In the current study, the PC12 cell line was used to examine the effect of NO on the regulation of the CA biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine- β -hydroxylase (DBH) and phenylethanolamine Nmethyltransferase (PNMT). Treatment of PC12 cells with the NO donor, sodium nitroprusside (SNP) for 6 hours significantly increased TH, DBH and PN...
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