Catalyst Free Synthesis of Pyridine-2,6-bis(2-bromo-propane-1,3-dione) and Pyrdine-2,6-bis(N-arylthiazoline-2-thiones)
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53965#.VN2pyyzQrzE Author(s) Korany A. Ali 1* , Mohamed A. Elsayed 1 , Eman Ali Ragab 2 Affiliation(s) 1 Applied Organic Chemistry Department, National Research Centre, Dokki-Giza, Egypt . 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt . ABSTRACT We have described herein a catalyst-free preparation method of pyridine-2,6-bis(N-alkylthiazoline-2-thiones) (4a-i) by the reaction of primary amines, CS 2 , and pyridine-2,6-bis(2-bromo-1,3- dicarbonyl) derivatives (2a-c) in water. Also, we have described a catalyst free, green chemistry protocols to monobromination of pyridine-2,6-bis(2-bromo-1,3-dicarbonyl) derivatives with high yield, using NBS as a brominating agent, that led to eco-friendly isolation and purification proce-dures. Furthermore, we have studied the reactivity of pyridine-2,6-bis(2-bromo-1-methyl-pro- pane-1,...