Scientific Research Publishing

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53743#.VNHFBizQrzE Author(s)  Jeff B. Helms 1,2* , Lauren P. Saunders 2 , Jamie Meyer 2 , Charles J. Costa 2 , Eric Plowman 2 , Nick Williford 1 , Matthew Corbitt 1 , Jeremy P. Holden 3 , Craig Gatto 2   Affiliation(s) 1 Department of Biology, Upper Iowa University, Fayette, IA, USA . 2 Division of Neuroscience and Physiology, Department of Biological Science, Illinois State University, Normal, IL, USA . 3 Department of Internal Medicine, University of Wisconsin-Madison Medical Center, Madison, WI, USA . ABSTRACT N-acetylbenzoquinoneimine (NABQI) is a toxic metabolite of the common analgesic acetaminophen (APAP). NABQI is an electrophilic intermediate formed via the oxidation of APAP within the cytochrome P450 system. Within the normally recommended low-dose use of APAP, NABQI is a minor metabolite which is either quickly reduced back to APAP or conjugated...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52874#.VKtJp8nQrzE Author(s)    Rosivaldo S. Borges 1* , Tainá G. Barros 1 , Glaécia A. N. Pereira 1 , João Batista Jr. 1 , Raimundo F. G. P. Beleza Filho 1 , Andrex A. S. Veiga 1 , Moisés Hamoy 2 , Vanessa J. Mello 2 , Albérico B. F. da Silva 3 , Carlos A. L. Barros 1 Affiliation(s) 1 Núcleo de Estudos e Seleção de Moléculas Bioativas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil . 1 Núcleo de Estudos e Seleção de Moléculas Bioativas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil . 2 Laboratório de Farmacologia e Toxicologia de Produtos Naturais, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil . 3 Institut...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=47156#.VGBOvmfHRK0 Author(s) Sonia Di Berardino , Renata Jasionowska Affiliation(s) Department of Chemistry, Sapienza University, Rome, Italy . Department of Chemistry, Sapienza University, Rome, Italy . ABSTRACT A rapid and sensitive CZE (Capillary Zone Electrophoresis) method for pharmaceutical analysis was developed and fully validated. The active compounds: Pseudoephedrine hydrochloride (PSE), Triprolidine hydrochloride (TRI) and Paracetamol (PAR) were separated and quantitatively determined using the tris-borate 30 mM buffer at pH = 9.0 as a Background Electrolyte (BGE). The electrophoretic separation was carried out at 25 ...