Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53794#.VNMhZyzQrzE Author(s) Miki Goto 1 , Hiroshi Mizuma 1 , Yasuhiro Wada 1 , Masaaki Suzuki 2 , Hirotaka Onoe 1* , Hisashi Doi 1* Affiliation(s) 1 Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan . 2 National Center for Geriatrics and Gerontology, Obu, Japan . ABSTRACT Synthesis of 11 C-labeled capsaicin ([ 11 C]-2) was accomplished by O-[ 11 C]methylation with [ 11 C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [ 11 C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [ 11 C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1. KEYWORDS PET , Capsaicin , 11 C-Labeling , TRPV1 , B...
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