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11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography

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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53794#.VNMhZyzQrzE

ABSTRACT
Synthesis of 11C-labeled capsaicin ([11C]-2) was accomplished by O-[11C]methylation with [11C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [11C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [11C]-2 accumulated in the brain and body surface, which was closely associated with the expression of transient receptor potential vanilloid 1.
 
Cite this paper
Goto, M. , Mizuma, H. , Wada, Y. , Suzuki, M. , Onoe, H. and Doi, H. (2015) 11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography. Food and Nutrition Sciences, 6, 216-220. doi: 10.4236/fns.2015.62022.
 
References
[1]Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. and Julius, D. (1997) The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway. Nature, 389, 816-824.
http://dx.doi.org/10.1038/39807
 
[2]Bandell, M., Macpherson, L.J. and Patapoutian, A. (2007) From Chills to Chilis: Mechanisms for Thermosensation and Chemesthesis via ThermoTRPs. Current Opinion in Neurobiology, 17, 490-497.
http://dx.doi.org/10.1016/j.conb.2007.07.014
 
[3]Gharat, L. and Szallasi, A. (2007) Medicinal Chemistry of the Vanilloid (Capsaicin) TRPV1 Receptor: Current Knowledge and Future Perspectives. Drug Development Research, 68, 477-497.
http://dx.doi.org/10.1002/ddr.20218
 
[4]Miller, P.W., Long, N.J., Vilar, R. and Gee, A.D. (2008) Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography. Angewandte Chemie International Edition, 47, 8998-9033.
http://dx.doi.org/10.1002/anie.200800222
 
[5]Roberts, J.C., Davis, J.B. and Benham, C.D. (2004) [3H]Resiniferatoxin Autoradiography in the CNS of Wild-Type and TRPV1 Null Mice Defines TRPV1 (VR-1) Protein Distribution. Brain Research, 995, 176-183.
http://dx.doi.org/10.1016/j.brainres.2003.10.001
 
[6]Wang, B., Yang, F., Shan, Y., Qiu, W. and Tang, J. (2009) Highly Efficient Synthesis of Capsaicin Analogues by Condensation of Vanillylamine and Acyl Chlorides in a Biphase H2O/CHCl3 System. Tetrahedron, 65, 5409-5412.
http://dx.doi.org/10.1016/j.tet.2009.04.046                                                                        eww150205lx
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