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http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53794#.VNMhZyzQrzE
Author(s)
Affiliation(s)
1Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies (CLST), Kobe, Japan.
2National Center for Geriatrics and Gerontology, Obu, Japan.
2National Center for Geriatrics and Gerontology, Obu, Japan.
ABSTRACT
Synthesis of 11C-labeled capsaicin ([11C]-2) was accomplished by O-[11C]methylation with [11C]-methyl iodide to a corresponding catechol precursor (1). In Vivo whole-body distribution of [11C]-2 in rats was investigated by positron emission tomography after intravenous injection. The results showed that [11C]-2
accumulated in the brain and body surface, which was closely associated
with the expression of transient receptor potential vanilloid 1.
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References
Goto, M. , Mizuma, H. , Wada, Y. , Suzuki, M. , Onoe, H. and Doi, H. (2015) 11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography. Food and Nutrition Sciences, 6, 216-220. doi: 10.4236/fns.2015.62022.
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