Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53000#.VK9BqsnQrzE Author(s) Diego J. S. Dias 1,2 , Graziella A. Joanitti 3 , Ricardo B. Azevedo 2 , Luciano P. Silva 4 , Claure N. Lunardi 1,3 , Anderson J. Gomes 1,3* Affiliation(s) 1 School of Health Sciences, University of Brasilia, Brasilia, Brazil . 2 Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil . 3 Laboratory of Nanobiotechnology, Faculty of Ceilandia, University of Brasilia, Brasilia, Brazil . 4 Laboratory of Mass Spectrometry, EMBRAPA, Genetic Resources and Biotechnology, Brasilia, Brazil . ABSTRACT The present work aimed to develop and evaluate a colloidal system composed of poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) associated with chlorambucil (CHB) and its effects on cancer cells. The nanoparticles showed %EE (>92%), a mean particle size in the range of 240 to 334 nm and zeta potential of -16...
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