Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Amino Phenyl)-3-Thioxo-1,2,4-Triazin-5(2H, 4H)One and Their Related Alkylated Systems as Molluscicidal Agent as against the Snails Responsible for Bilharziasis Diseases
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=47413#.VMicAyzQrzE Author(s) Abeer N. Al-Romaizan , Mohammed S. T. Makki , Reda M. Abdel-Rahman Affiliation(s) Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, KSA . Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, KSA . Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, KSA . ABSTRACT New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazi...