Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52328#.VJDbxcnQrzE Author(s) Reda M. Abdel-Rahman , Mohammed S. T. Makki , Abeer N. Al-Romaizan * Affiliation(s) Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, KSA . ABSTRACT Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 ...