IL-10 Gene Knockout Reduces the Expression of mGlu Receptor 1a/b and Decreases the Glutamate-Dependent Production of Nitric Oxide
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51240#.VGAYc2fHRK0 Author(s) Sopiko Koriauli 1 , Tamar Barbakadze 1,2 , Nino Natsvlishvili 1,2 , Nino Dabrundashvili 3 , Eka Kvaratskhelia 3 , David Mikeladze 1,2* Affiliation(s) 1 Ilia State University, Tbilisi, Georgia . 2 Ilia State University, Tbilisi, Georgia . 2 I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia . 3 Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia . ABSTRACT IL-10 provides trophic and survival effects directly on neurons, promotes axonal outgrowth, and stimulates neuroregeneration. In this study, we analyzed the activities of arginase and nitric oxid...