Inhibition of EGFR Suppresses Ethyl Alcohol and Tobacco Cell Effects on Growth of Human Oral Keratinocytes and Human Papillomavirus 16 Entry as a Function of Furin
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53402#.VMG11CzQrzE Author(s) Joel L. Schwartz 1 , Alexander Munaretto 2 , Sirlata Bagchi 3 , David Crowe 3 , Gonzalo Izaguirre 3 Affiliation(s) 1 Department of Oral Medicine and Diagnostics, University of Illinois at Chicago, Chicago, USA . 2 College of Dentistry, University of Illinois at Chicago, Chicago, USA . 3 Department of Periodontics, University of Illinois at Chicago, Chicago, USA . ABSTRACT Background: Reported are increased risks for malignant transformation in human oral keratinocytes (HOK) from ethyl alcohol (ETOH), tobacco products or human papilloma virus oncogenic subtype 16 (HPV 16) infections. We examined various HOK cell responses to these factors to show inhibitors of epidermal growth factor receptor (EGFR) also inhibits furin; proprotein convertase (FC) and HPV 16 entry in HOK. Methods: Immortalized HOK by HPV 16 (HPV 16B) ...