Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52659#.VKCoXcCAM4 Author(s) Jun-Ichi Yamaguchi * , Emiko Shibuta , Yoshie Oishi Affiliation(s) Department of Applied Chemistry, Kanagawa Institute of Technology, Atsugi, Japan . ABSTRACT The reduction of various hydantoins with sodium borohydride gave the corresponding 4-hydroxy- 2-imidazolidinones in high yields. In contrast, reduction employing a boron trifluoride etherate-sodium borohydride system generated 2-imidazolidinones. In both reductions, the reactivity of the hydantoin was dependent on its substituents. The Lewis acid-promoted reactions of a 4-hydroxy-2-imidazolidinone with nucleophiles were also investigated. ...
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