Effect of ALDH2 Genetic Polymorphism on the Adaptive Change in Alcohol Metabolism Due to Continuous Moderate Alcohol Consumption in Humans
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53733#.VNB6LSzQrzE Author(s) Shunji Oshima 1* , Takeshi Haseba 2 , Akihiro Nemoto 1 , Sachie Siiya 1 , Tomomasa Kanda 1 , Youkichi Ohno 2 Affiliation(s) 1 Research & Development Laboratories for Innovation, Asahi Group Holdings, Ltd., Ibaraki, Japan . 2 Department of Legal medicine, Nippon Medical School, Tokyo, Japan . ABSTRACT Few studies have assessed the difference in adaptive changes of alcohol metabolism in the case of chronic alcohol consumption pertaining to the genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) in humans. To evaluate the influences of ALDH2 genotypes on changes in alcohol metabolism due to continuous alcohol intake, we conducted an intervention study by setting a continuous drinking period between two abstinence periods. The subjects in this study comprised 20 - 25-year-old males, including 15 males carrying ALDH2...