Scientific Research Publishing

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51253#.VGAezGfHRK0 Author(s)   Istvan Berczi 1,2 Affiliation(s) 1 Department of Immunology, University of Manitoba, Winnipeg, Canada . 2 Department of Physiology, The University of Aguascalientes, Aguascalientes, Mexico . ABSTRACT We examined the possibility that the anti-estrogens, tamoxifen (TX) and toremifen (TO) interacted   with the immune system. Indeed, both TX and TO stimulated cells mediated cytotoxicity reactions by various killer cells: killer T (TK), natural killer (NK), lymphokine activated killer (LAK) cells. Both TX and TO inhibited the growth of tumors that express estrogen receptors. Thus these antiestrogens in...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50850#.VE3YgFfHRK0 Author(s)   Spencer Keene , Charles Azuelos , Shyamal K. Majumdar Affiliation(s) Department of Biology, Lafayette College, Easton, PA, USA . ABSTRACT Tamoxifen citrate (TAM) has been used to treat breast cancer in women for many years. The com-parative effects of TAM in inducing apoptosis were evaluated in estrogen receptor-positive (ER- positive MCF-7) and estrogen receptor-negative (ER-negative MDA-MB-231) human breast cancer cell lines in vitro in order to determine if these two cell lines differ in their sensitivity to TAM. Mi-tochondrial membrane permeability potential disruption was assessed in both ...