Expression of Messenger RNA of Oncoproteins E6 and E7 of Human Papilomavirus in Women with Negative Oncotic Cytologies, Epithelial Squamous Atypias of Undefined Significance and Low-Grade Intraepithelial Lesions
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52945#.VK3YEsnQrzE Author(s) Daiene Carvalho Casagrande , Julisa Chamorro Lascasas Ribalta , Katia de Araujo Prado Ferreira Leite , Manoel Schimidt , Neila Maria de Góis Speck * Affiliation(s) Department of Gynecology, Escola Paulista de Medicina (UNIFESP), Sao Paulo, Brazil . ABSTRACT Objectives: To verify the prevalence of E6/E7 RNAm expression of HPV in patients with negative cervicovaginal cytology, ASC-US and LSIL; to correlate with negative anatomopathological exams and/or squamous intraepithelial neoplasy grade I (SIN 1) of the lower genital tract (LGT); to relate the RNAm expression with viral infection types; to assess the genotyping in single infections. Methods: Findings from 825 women submitted to E6/E7 RNAm survey and 422 women submitted to LGT biopsies were analyzed. Results: A larger percentage of E6/E7 in ASC-US and LSIL cytologies occurred. Negative...