Scientific Research Publishing

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53301#.VLydj8nQrzE Author(s)    Yukihiro Hirao * , Toshihisa Koga , Noriyuki Koyama , Yoshihiko Shimokawa , Ken Umehara Affiliation(s) Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima-shi, Japan . ABSTRACT Sensitive and selective liquid chromatography-tandem mass spectrometry methods have been developed and validated for the determination of delamanid in mouse plasma and lung. Sample preparation involved liquid-liquid extraction with diethyl ether for plasma, or protein precipitation followed by liquid-liquid extraction with tert -butyl methyl ether for lung homogenate. Chromatographic separation was performed on a reversed phase column with a linear gradient elution using purified water-formic acid (1000:2, v/v) and methanol-formic acid (1000:2, v/v) at a flow rate of 0.2 mL/min. Detection was performed on a triple-quadrupole ...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51061#.VFMBLWfHRK0 Author(s)      Leave a commen     Phak-Rop Pos Pok , Emilie Berland , Michel Mauras , Magali Valès , Erika Kuhlmann Affiliation(s) Laboratoire de Police Scientifique de Marseille, Section Toxicologie, Institut National de Police Scientifique, France . ABSTRACT A case of suspected poisoning by benzodiazepines is presented in this paper. Toxicological analyses were applied on the blood collected 48 hours after the facts. GC-MS and HPLC-DAD have detected only nordiazepam which was prescribed in the treatment. Therefore, LC-MS/MS has detected lormetazepam and lorazepam (major meta...

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50971#.VFG4I1fHRK0 Author(s) Samia Mokh 1 , Farouk Jaber 1 , Abir Kouzayha 1 , Hélène Budzinski 2 , Mohamad Al Iskandarani 1,3* Affiliation(s) 1 Laboratory for Analysis of Organic Compound (LACO), Lebanese Atomic Energy Commission (LAEC), National Council for Scientific Research (CNRS), Beirut, Lebanon . 2 ISM-LPTC-UMR 5255 (Laboratory of Physico and Toxico Chemistry), CNRS, Bordeaux University 1, Talence, France . 3 Faculty of Public Health, Lebanese University, Beirut, Lebanon . ABSTRACT Aminoglycosides are a family of antibiotics with important applications in veterinary medicine. Their ionic character, the similarity structu...