Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53391#.VMBv-yzQrzE Author(s) Katharina Anne Scherf * , Peter Koehler , Herbert Wieser Affiliation(s) Deutsche Forschungsanstalt für Lebensmittelchemie, Leibniz Institut, Freising, Germany . ABSTRACT Celiac disease is a permanent intolerance to gluten proteins of wheat, rye, barley, and oats in genetically susceptible individuals. The clinical picture is characterized by inflammation and damage of the small intestinal mucosa and malabsorption of essential nutrients. Therapeutically, a lifelong strict gluten-free diet is necessary. The diagnosis of celiac disease is complex and includes symptomatology, serology, small intestinal histology, and genetic status. Serological testing plays a central role within the diagnostic procedure and is based on the measurement of disease-specific antibodies against gluten proteins (antigen) and tissue transgl...
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