Gap Junctional Intercellular Communication Increases Cytotoxicity and Reduces Resistance to Hydroxyurea
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51255#.VGAezWfHRK0 Author(s) Randall J. Ruch 1* , Paul D. Boucher 2 , Brian G. Gentry 2,3 , Donna S. Shewach 2 Affiliation(s) 1 Department of Biochemistry and Cancer Biology, University of Toledo, Toledo, USA . 2 Department of Pharmacology, University of Michigan, Ann Arbor, USA . 3 Drake University College of Pharmacy and Health Sciences, Des Moines, USA . ABSTRACT Background: Gap junctions enable small molecules to diffuse between adjacent cells and have been associated with greater cytotoxicity of radiation and anti-cancer drugs. We investigated whether this gap junctional intercellular communication (GJIC) affected the cyt...