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目前显示的是标签为“PROSTATE CANCER”的博文

Erratum to “Inflammation and Its Role in Prostate Cancer”

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53565#.VMiUKizQrzE Author(s)    Rakesh K. Mishra , Ashutosh K. Tewari *   Affiliation(s) Department of Urology, Icahn School of Medicine at Mount Sinai, New York, USA . ABSTRACT Inflammation is associated with various cancers, and plays a significant role in prostate cancer genesis including initiation, promotion, malignant conversion, invasion, and metastasis. While several studies posit an important role of inflammation in prostate growth, the exact mechanisms are not known. The extant basic and clinical research in the area, trying to unravel the etiology of prostatic inflammation and its signaling pathway, may help to develop novel therapeutic interventions against prostate cancer development triggered by inflammation. KEYWORDS Prostate Cancer , Inflammation , Signaling Cite this paper Mishra, R. and Tewari, A. (2015) Erratum to...

Following Inhibition of BCL-2 by Antisense Oligonucleotides Compensatory Suppression of Apoptosis Involves the Direct Signal Transduction Pathway of LNCaP Cells

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53041#.VLSJbsnQrzE Author(s)    Marvin Rubenstein 1,2,3,4* , Courtney M. P. Hollowell 4 , Patrick Guinan 1,3,4,5   Affiliation(s) 1 Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL, USA . 2 Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA . 3 Department of Urology, Rush University Medical Center, Chicago, IL, USA . 4 Division of Urology, Stroger Hospital of Cook County, Chicago, IL, USA . 5 Department of Urology, University of Illinois at Chicago, Chicago, IL, USA . ABSTRACT Previously we have shown that when LNCaP cells are treated with antisense oligonucleotides (oligos) directed against BCL-2, compensatory changes in non-targeted genes take place in attempts to restore apoptosis and promote tumor aggressiveness. In addition to the inhibition of BCL-2, we find that the apoptosis promoter c...

Construction of a Simple Rectum Model Using Image Guidance in Prostate Patients Treated with 3D Conformal Radiotherapy

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50452#.VD9yDlfHRK0 Author(s)   Marco D’Andrea 1* , Maria Daniela Falco 2 , Dahlia Fedele 2 , Elisabetta Ponti 2 , Barbara Tolu 2 , Daniela Di Cristino 2 , Rosaria Barbarino 2 , Luana Di Murro 2 , Grazia Tortorelli 2 , Andrea Duggento 3 , Paolo Bagalà 2,3 , Maria Guerrisi 3 , Riccardo Santoni 2 Affiliation(s) 1 Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, Rome, Italy . 2 Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, Rome, Italy . 3 Department of Biomedicine and Prevention, Medical Physics Section, Tor Vergata University, Rome, Italy . ABSTRA...

Taking Fish Oil? Think again

2013 was a very bad year for fish oil with 3 horrific failures. The world’s leading medical journals published their failures but too few patients were made aware.  First, fish oil’s monumental failure to help heart disease as published in   The New England Journal of Medicine  caused editor-in-chief of  Medscape  and the heart.org, cardiologist Eric Topol, MD, stated I implore them [patients] to stop taking it [fish oil] because there was “No benefit of fish oil in high risk patients.”  Next, the SELECT Trial published in  Journal of the National Cancer Institute , confirmed previous devastating results showing fish oil increases prostate cancer risk in men, even greater than harmful transfats cause. Fish oil failed to stop macular degeneration even in patients with low DHA  ( Journal of the American Medical Association ) . In 2010, fish oil failed to help Alzheimer’s victims; even those with low DHA  ( Journal of the American Medical Asso...