Sensitivity Evaluation of Two Human Breast Cancer Cell Lines to Tamoxifen through Apoptosis Induction
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50850#.VE3YgFfHRK0 Author(s) Spencer Keene , Charles Azuelos , Shyamal K. Majumdar Affiliation(s) Department of Biology, Lafayette College, Easton, PA, USA . ABSTRACT Tamoxifen citrate (TAM) has been used to treat breast cancer in women for many years. The com-parative effects of TAM in inducing apoptosis were evaluated in estrogen receptor-positive (ER- positive MCF-7) and estrogen receptor-negative (ER-negative MDA-MB-231) human breast cancer cell lines in vitro in order to determine if these two cell lines differ in their sensitivity to TAM. Mi-tochondrial membrane permeability potential disruption was assessed in both ...