Implicit Hypotheses Are Hidden Power Droppers in Family-Based Association Studies of Secondary Outcomes
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53677#.VM8uZSzQrzE Author(s) Jean Gaschignard 1,2 , Quentin B. Vincent 1,2 , Jean-Philippe Jaïs 1,2,3 , Aurélie Cobat 1,2 , Alexandre Alcaïs 1,2,4 Affiliation(s) 1 Laboratoire de Génétique des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, Paris, France . 2 Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine, Paris, France . 3 Biostatistique et Informatique Médicale, Hôpital Necker, Paris, Farnce . 4 URC, CIC, Necker and Cochin Hospitals, Paris, France . ABSTRACT Family-based tests of association between a genetic marker and a disease constitute a common design to dissect the genetic architecture of complex traits. The FBAT software is one of the most popular tools to perform such studies. However, researchers are also often interested in the genetic contribution to a more specific manifestat...