Development and Validation of a Stability-Indicating RP-HPLC Method for Determination of Darifenacin Hydrobromide in Bulk Drugs
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52387#.VJOMGcCAM4 Author(s) Mohammed Nazeerunnisa 1 , Lakshmi Garikapati 2 , Syama Sundar Bethanabhatla 1,3* Affiliation(s) 1 Department of Chemistry, Acharya Nagarjuna University, Guntur, India . 2 Centre for Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, India . 3 Yogi Vemana University, Kadapa, India . ABSTRACT An isocratic stability-indicating reversed phase high performance liquid chromatographic method (RP-HPLC) was developed for determination of process related impurities and assay of darifenacin hydrobromide (DRF) in bulk drugs. DRF was subjected to various stress conditions such as hydrol...