Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode Laser for Superficial Tumors in Experimental Animals
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53220#.VLcsZcnQrzE Author(s) Tohru Obata 1* , Satoru Mori 2 , Yuka Suzuki 1,2 , Takuto Kashiwagi 1 , Etsuko Tokunaga 2 , Norio Shibata 2 , Motohiro Tanaka 1 Affiliation(s) 1 Department of Bioorganic Chemistry, Faculty of Pharmaceutical Sciences, Aichi-Gakuin University, Nagoya, Japan . 1 Department of Bioorganic Chemistry, Faculty of Pharmaceutical Sciences, Aichi-Gakuin University, Nagoya, Japan . 2 Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan . ABSTRACT Photodynamictherapy (PDT) using a photo sensitizing agent and several light sources has been shown to have nonspecific and noninvasive effects on superficial cancers. Phthalocyanine (Pc) derivatives as novel photosensitizers, trifluoroethoxy-coatedzinc Pcconjugated with β -cyclodextrin ( β CD-4TFEO-Pc) was synthesized and its photodynam...