Mathematical Modeling of a Metabolic Network to Study the Impact of Food Contaminants on Genomic Methylation and DNA Instability
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52345#.VJJI5MnQrzE Author(s) Etienne Z. Gnimpieba 1* , Souad Bousserouel 2 , Abalo Chango 1 Affiliation(s) 1 Department of Nutritional Sciences and Health, EGEAL UPSP: 2007.05.137-Institut Polytechnique Lasalle Beauvais, Beauvais, France . 2 Laboratoire de Prévention Nutritionnelle du Cancer, Inserm U682-IRCAD, Strasbourg, France . ABSTRACT Environmental contamination of food is a worldwide public health problem. Folate mediated one- carbon metabolism plays an important role in epigenetic regulation of gene expression and mutagenesis. Many contaminants in food cause cancer through epigenetic mechanisms and/or DNA instability i.e. ...