Design and in Vitro Evaluation of Eudragit® S100/Lipid Based Simvastatin Chronotherapeutic Drug Delivery System
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52701#.VKDJJcCAM4 Author(s) Ehab I. Taha 1,2 Affiliation(s) 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt . 2 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia . ABSTRACT The present study was undertaken to 1) formulate a pulsatile colonic delivery of simvastatin (SIM) as chronotherapy for treatment of hypercholesterolemia, and 2) enhance the dissolution profile of the prepared SIM chronotherapeutic system. Lipid based formulations were utilized to formulate SIM in capsule dosage form coated with Eudragit ® ...