Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51181#.VFm9l2fHRK0 Author(s) Tyler Downing , Amy Mangla , Michael Banta , Suguru Nakamura Affiliation(s) Department of Biological Sciences, Jesse D. Jones College of Science, Engineering and Technology, Murray State University, Murray, USA . ABSTRACT The H-K-ATPase (HKA), a potassium-dependent proton transporter in the outer medullary collecting duct (OMCD) plays an important role in acid-base homeostasis. The OMCD contains two HKA isoforms; gastric (HKA α 1), dominant under normal dietary conditions (ND), and colonic (HKA α 2), induced under a K-free diet (KD). The enzymatic activity (EA) of HKA in the OMCD is incomplet...
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