Following Inhibition of BCL-2 by Antisense Oligonucleotides Compensatory Suppression of Apoptosis Involves the Direct Signal Transduction Pathway of LNCaP Cells
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53041#.VLSJbsnQrzE Author(s) Marvin Rubenstein 1,2,3,4* , Courtney M. P. Hollowell 4 , Patrick Guinan 1,3,4,5 Affiliation(s) 1 Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL, USA . 2 Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA . 3 Department of Urology, Rush University Medical Center, Chicago, IL, USA . 4 Division of Urology, Stroger Hospital of Cook County, Chicago, IL, USA . 5 Department of Urology, University of Illinois at Chicago, Chicago, IL, USA . ABSTRACT Previously we have shown that when LNCaP cells are treated with antisense oligonucleotides (oligos) directed against BCL-2, compensatory changes in non-targeted genes take place in attempts to restore apoptosis and promote tumor aggressiveness. In addition to the inhibition of BCL-2, we find that the apoptosis promoter c...