Kinetic Monte Carlo Study of the Type 1/ Type 2 Choice in Apoptosis Elucidates Selective Killing of Cancer Cells under Death Ligand Induction
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53418#.VMG9TizQrzE Author(s) Subhadip Raychaudhuri Affiliation(s) Department of Computational Biology, Indraprastha Institute of Information Technology-Delhi, New Delhi, India . ABSTRACT Death ligand mediated apoptotic activation is a mode of cell death that is widely used in cellular and physiological situations. Interest in studying death ligand induced apoptosis has increased due to the promising role of recombinant soluble forms of death ligands (mainly recombinant TRAIL) in anti-cancer therapy. A clear elucidation of how death ligands activate the type 1 and type 2 apoptotic pathways in healthy and cancer cells may help develop better chemotherapeutic strategies. In this work, we use kinetic Monte Carlo simulations to address the problem of type 1/ type 2 choice in death ligand mediated apoptosis of cancer cells. Our study provides insig...