(E)-2-Benzylidenecycloalkanones XII.* Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53659#.VM8m6izQrzE Author(s) Beáta Veliká 1 , Vladimíra Tomečková 1 , Krisztina Fodor 2 , Ivan Kron 1 , Pál Perjési 2* Affiliation(s) 1 Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine UPJS, Trieda SNP 1, Kosice, Slovakia . 2 Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary . ABSTRACT UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute tim...