Scientific Research Publishing

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53725#.VNB0kizQrzE Author(s)    Isam I. Salem * , Mahmoud Abdullah , Naji Najib Affiliation(s) International Pharmaceutical Research Center (IPRC), Amman, Jordan . ABSTRACT A stereoselective, sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MSMS) method for the determination of R-acenocoumarol and S-acenocoumarol in human plasma was developed and validated at IPRC bioanalytical labs. The procedure involved solid phase extraction of both enantiomers and their corresponding internal standard. The chromatographic separation was accomplished employing a chiral column and proper mobile phase. Detection was carried out using Waters Micromass ® Quattro Premier mass spectrometer in multiple reaction monitoring (MRM) mode using turbo ion spray with negative ionization. The method was validated over a linear range of 0.40 - 40.00 ng/m...

Read  full  paper  at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52923#.VKygQsnQrzE Author(s)   G. Yang 1 , D. Kechkeche 2 , H. Belhadj-Tahar 3 , N. Sadeg 3   Affiliation(s) 1 School of Medicine, Tongji University, Shanghai, China . 2 Departement of Chemistry, University of Pierre et Marie-Curie, Paris, France . 3 AFPreMed, Toxicology Research Group, Toulouse, France . ABSTRACT The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)). All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial...