Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53912#.VNsLbyzQrzE Author(s) Ruth Gallily 1 , Zhannah Yekhtin 1 , Lumír Ondřej Hanuš 2 Affiliation(s) 1 The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel . 2 Department of Medicinal and Natural Products, Institute for Drug Research, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel . ABSTRACT Cannabidiol (CBD), a major constituent of Cannabis , has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use. In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extr...