Induction of Oral Tolerance in Neonatal Mice by Transfer of Food Allergens as IgA-Immune Complexes in Breast Milk
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53930#.VNxhYizQrzE Author(s) Kumiko Kizu 1 , Ayu Matsunaga 2 , Junko Hirose 3 , Akihiro Kimura 4 , Hiroshi Narita 2 Affiliation(s) 1 Department of Life and Living, Osaka Seikei College, Osaka, Japan . 2 Department of Food and Nutrition, Kyoto Women’s University, Kyoto, Japan . 3 Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan . 4 Itayado Clinic, Kobe, Japan . ABSTRACT Various opinions have been presented on the merits and demerits that breastfeeding gives for the allergic onset of the babies. In this report, we focused on whether food proteins eaten by mother mice and secreted into breast milk as IgA-immune complexes contribute to the allergy prevention through oral tolerance in infants who ingest the milk. BALB/c mice were divided into two groups; E-group fed only egg white p...