Development and Validation of RP-UPLC Method for the Determination of Iloperidone, Its Related Compounds and Degradation Products in Bulk and Dosage Form
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50970#.VFG4IFfHRK0 Author(s) Shashikant B. Landge , Sanjay A. Jadhav , Shrihari P. Vishwambar , Pavankumar V. Solanki , Saroj R. Bembalkar , Vijayavitthal T. Mathad * Affiliation(s) Research and Development, Megafine Pharma (P) Ltd., Nashik, India . ABSTRACT A rapid, specific, sensitive, and precise reverse-phase UPLC method developed for the quantitative determination of an atypical antipsychotic drug Iloperidone and its eight potential impurities in drug substances and drug products is described in this report. Chromatographic separation was achieved on a Waters Acquity UPLC® HSS C18 (2.1 mm × 100 mm, 1.8 micron) column the...