Resolution of Late Steroid-Responsive Nephrotic Syndrome in a Patient with Alport Syndrome Treated with Atorvastatin
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53730#.VNB6JCzQrzE Author(s) Jia-Feng Chang 1,2 , Wei-Ning Lin 1 , Chien-Chen Tsai 3* Affiliation(s) 1 Graduate Institute of Basic Medicine, Fu Jen Catholic University, Taipei, Taiwan . 2 Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan . 3 Department of Anatomic Pathology, Far Eastern Memorial Hospital, New Taipei City, Taiwan . ABSTRACT Experimental and clinical studies have pointed out the lipid-induced renal damage, and statins may have pleiotropic effects on renoprotection. We reported a girl with X-linked Alport syndrome whose late steroid-responsive nephrotic syndrome (NS) was resolved by atorvastatin. She had been in a nephrotic condition despite of prednisone therapy 60 mg/day for 8 weeks. Renal biopsy dispicted extreme foamy appearance of tubular epithelial cells with detachment...