MINS, a Novel Naphthalimide-Polyamine Conjugate, Induced Apoptosis Depending on p53 Status in Human Colon Cancer Cells
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=50849#.VE3YfVfHRK0 Author(s) Ming Li 1 , Tao Yang 1 , Fujun Dai 2 , Qian Li 2 , Yahong Zhang 2 , Songqiang Xie 1* , Chaojie Wang 2* Affiliation(s) 1 Institute of Chemical Biology, Pharmaceutical College of Henan University, Kaifeng, China . 2 The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China . ABSTRACT Natural polyamine is an ideal antitumor drug carrier because of the great requirement difference between cancer cells and normal cells. Previous data demonstrated that many cytotoxic drugs conjugated with natural or synthetic polyamines have potent antitumor effects. Up to now,...