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博文

目前显示的是标签为“Metabotropic Glutamate Receptor”的博文

Differential Expression of mGluR2 in the Developing Cerebral Cortex of the Mouse

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51241#.VGAaXWfHRK0 Author(s) Pooja S. Venkatadri , Charles C. Lee Affiliation(s) Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, USA . ABSTRACT Glutamatergic synaptic transmission is an essential component of neural circuits in the central nervous system. Glutamate exerts its effects by binding to various types of glutamate receptors, which are found distributed on neurons throughout the central nervous system. These receptors are broadly classified into two main groups, ionotropic glutamate receptors (iGluRs) and metabo-tropic glutamate receptors (mGluRs). U...

IL-10 Gene Knockout Reduces the Expression of mGlu Receptor 1a/b and Decreases the Glutamate-Dependent Production of Nitric Oxide

Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51240#.VGAYc2fHRK0 Author(s) Sopiko Koriauli 1 , Tamar Barbakadze 1,2 , Nino Natsvlishvili 1,2 , Nino Dabrundashvili 3 , Eka Kvaratskhelia 3 , David Mikeladze 1,2* Affiliation(s) 1 Ilia State University, Tbilisi, Georgia . 2 Ilia State University, Tbilisi, Georgia . 2 I. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia . 3 Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia . ABSTRACT IL-10 provides trophic and survival effects directly on neurons, promotes axonal outgrowth, and stimulates neuroregeneration. In this study, we analyzed the activities of arginase and nitric oxid...