Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
Read full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53972#.VN2sTSzQrzE Author(s) Michele Ciccarelli 1 , Mariarosaria Rusciano 2 , Daniela Sorriento 3 , Angela Serena Maione 2 , Maria Soprano 2 , Guido Iaccarino 1,4 , Maddalena Illario 2* Affiliation(s) 1 Department of Medicine and Surgery, University of Salerno, Salerno, Italy . 2 Department of Clinical and Translational Medicine, Federico II University, Napoli, Italy . 3 IBP, CNR, Napoli, Italy . 4 IOS e Coleman, Napoli, Italy . ABSTRACT Cancer is a multistep process encompassing the transformation of normal epithelial cells to the stromal invasion and metastasis, with these last considered the final stage of the disease. Tumor invasiveness is based on creation of a specific peri-tumoral environment which on turn depends upon epithelial-stromal interactions, degradation of extracellular matrix and reorganization of fibrillar components. Even thou...